Experimental infection of mouse peritoneal mesothelium with scrub typhus rickettsiae: an ultrastructural study
نویسندگان
چکیده
منابع مشابه
Fever and Scrub Typhus Rickettsiae
The rickettsiae have always been difficult to study because convenient titration and isolation techniques have not been available for the study of these organisms. In recent reports (3, 5), however, we demonstrated the use of a sensitive plaque test for measuring concentrations of typhus and spotted fever rickettsiae. Studies were then initiated to determine whether this assay system is appropr...
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Scrub typhus immunogens that received inadequate gamma radiation contained residual, viable rickettsiae. The presence of these organisms in the host was masked by the rapid immune response elicited by the large number of inactivated rickettsiae. Transfer of homogenized spleen cells from immunized mice to normal syngeneic recipients provided a sensitive technique for the detection of these viabl...
متن کاملAn Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection
Scrub typhus is a neglected tropical disease, caused by Orientia tsutsugamushi, a Gram-negative bacterium that is transmitted to mammalian hosts during feeding by Leptotrombidium mites and replicates predominantly within endothelial cells. Most studies of scrub typhus in animal models have utilized either intraperitoneal or intravenous inoculation; however, there is limited information on infec...
متن کاملScrub Typhus--A Re-Emerging Infection.
chills and rigors, headache, vomiting, cough which are all non-specific. Out of all the patients with pyrexia of intermediate duration studied, 10 had hepatosplenomegaly and only 1 scrub typhus positive patient had the sign and 1 out of the total 92 patients had neck stiffness and he was positive for scrub typhus by PCR. None of them had an eschar which is supposed to be characteristic of ricke...
متن کاملHost defenses in experimental scrub typhus: role of spleen and peritoneal exudate lymphocytes in cellular immunity.
Lymphocytes obtained from spleens or peritoneal exudates of immune donor mice were evaluated for their ability to passively confer protection on recipients subsequently challenged with virulent scrub typhus rickettsiae. Peritoneal exudate lymphocytes (PELs) injected intraperitoneally were able to transfer complete protection against rickettsial challenge by 5 days after immunization, whereas sp...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1978
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.19.3.1068-1075.1978